The world´s sharpest eye

The qPlus® Sensor

qPlus®

An atomic force microscope with a qPlus® Sensor as its core exceeds all other microscopy techniques in spatial resolution, providing the sharpest images of the tiniest constituents of our world.

Conceptually, atomic force microscopy (AFM) is simple: a positioning device allows to raster scan a sharp tip mounted on a cantilever over a surface.
A computer records the traces and creates an image of the surface under study.

The sensor that holds the tip is the core of the AFM.

The qPlus® Sensor is a highly sensitive probe with utmost precision that enables the creation of the most precise and sharpest images of our world. It borrows from breakthroughs in the watch industry, where the introduction of quartz tuning forks enabled the making of highly precise and reliable watches.

Photo: National Institute of Materials Science (NIMS), Tsukuba, Japan (Nov 2024)

Message from Franz J. Giessibl

Inventor of the qPlus® Sensor

Welcome to the homepage of the qPlus sensor! The qPlus sensor is a powerful core of the atomic force microscope (AFM) that optimizes its spatial resolution and ease of use. The inquiry into the full potential of the qPlus sensor in AFM follows this strategy:

  1. Do cool experiments in own lab
  2. Share technology with other groups
  3. Make technology commercially available
  4. Write review papers, book chapters, books
  5. Teach tutorials

CV of Franz Giessibl

1982 Prediploma in Precision Engineering at University of Applied Sciences Munich
1982 – 1987 Studies in Physics and Mathematics at Technical University of Munich and Eidgenössische Technische Hochschule Zurich
1987 Thesis on Raman Scattering on SiGe Monolayer Superlattices with Gerhard Abstreiter
1988 Diplom-Physiker at Technical University of Munich
1988 – 1991 PhD thesis on low temperature atomic force microscopy in ultrahigh vacuum with Nobel Laureate Gerd Binnig at IBM Physics Group Munich / Ludwig Maximilians University of Munich
1992 Postdoctoral Fellow at IBM Physics Group Munich
1992-1993 Senior Scientist at Park Scientific Instruments, Sunnyvale, USA, lead designer of noncontact AFM for UHV
1994 First successful atomic resolution of Si 7×7 by AFM, published in Science Jan 1995
1994 Director of Vacuum Products at Park Scientific Instruments
1995-1996 Senior Associate with McKinsey & Company, invention of qPlus sensor in home laboratory, first patent applications in Germany and USA
1997 Permanent research staff member at Chair of Professor Jochen Mannhart, University of Augsburg
1999 First subatomic spatial resolution by AFM, achieved with qPlus sensor, published in Science in July 2000
2001 Venia legendi at University of Augsburg
2005 Offers for Chairs at University of Bristol, UK and Regensburg, Germany
2005-2010 Multiple research stays at the former Don Eigler low temperature STM group at IBM Research Laboratory Almaden with Andreas Heinrich
2006 Establishing Chair for Quantum Nanoscience at University of Regensburg
2011 Invention of next generation qPlus sensors, patents in D, USA, China
2014 Visiting Professor at National Institute of Standards and Technology (NIST) Gaithersburg, USA with Joseph Stroscio
2025 Visiting Professor at National University of Singapore (NUS) with Jiong Lu and Shaotang Song

Video portrait: https://mediathek2.uni-regensburg.de/playthis/648730a2d4f163.21781006

Atoms are tiny

The ratio between the diameter of an atom and the height of a human is similar to the ratio between the diameter of a pinhead and our earth.

Seeing "dents" in an atom - subatomic spatial resolution obtained with a qPlus® Sensor

Seeing "dents" in an atom - subatomic spatial resolution obtained with a qPlus® Sensor

Scanning tunneling microsocopy and atomic force microscopy can resolve atoms, where an atom is imaged as a blurry spot.

In the initial examples of subatomic resolution, the front atom of the sensor’s tip was imaged by the sample, revealing orbital structures of the tip’s front atom (left pair of images below).

In later examples of subatomic resolution, the metallic front atom of the sensor’s tip was terminated by a CO molecule, providing an ultrasharp tip that imaged single sample atoms (right pair of images below).

Left: Si tip atom, Fig. 3 in Science 289, 422 (2000).
Right: W tip atom, Fig. 4 in Science 305, 380 (2004).

Left: Fe atom, Fig. 1I in Science 348, 308 (2015).
Right: Cu atom, Fig. S1D in Science 348, 308 (2015).

Proof of concept

Significant works that utilize the qPlus® sensor may serve as a demonstration of its merits and spark the imagination for potential future applications. A very small selection of published results in various application fields is listed here.

A) Spatial resolution

  1. Imaging of organic molecules
    The Chemical Structure of a Molecule Resolved by Atomic Force Microscopy, Leo Gross, Fabian Mohn, Nikolaj Moll, Peter Liljeroth, Gerhard Meyer. Science 325, 1110 (2009). https://www.science.org/doi/10.1126/science.1176210
  2. Imaging of tiny molecules such as water
    Ultrahigh-resolution imaging of water networks by atomic force microscopy, Akitoshi Shiotari, Yoshiaki Sugimoto, Nature Communications 8, 14313 (2017).
    https://www.nature.com/articles/ncomms14313
    Imaging surface structure and premelting of ice Ih with atomic resolution, Jiani Hong, Ye Tian, Tiancheng Liang, Xinmeng Liu, Yizhi Song, Dong Guan, Zixiang Yan, Jiadong Guo, Binze Tang, Duanyun Cao, Jing Guo, Ji Chen, Ding Pan, Li-Mei Xu, En-Ge Wang, Ying Jiang, Nature 630, 375 (2024).
    https://www.nature.com/articles/s41586-024-07427-8
  3. Subatomic spatial resolution
    Subatomic Features on the Silicon (111)-(7×7) Surface Observed by Atomic Force Microscopy, Franz J. Giessibl, S. Hembacher, H. Bielefeldt, J. Mannhart, Science 289, 422 (2000).
    https://www.science.org/doi/10.1126/science.289.5478.422
    Subatomic resolution force microscopy reveals internal structure and adsorption sites of small iron clusters, Matthias Emmrich, Ferdinand Huber, Florian Pielmeier, Joachim Welker, Thomas Hofmann, Maximilian Schneiderbauer, Daniel Meuer, Svitlana Polesya, Sergiy Mankovsky, Diemo Ködderitzsch, Hubert Ebert, Franz J. Giessibl, Science 348, 308 (2015).
    https://www.science.org/doi/10.1126/science.aaa5329

B) Special physical and chemical experiments

  1. Surface science of insulators
    Direct assessment of the acidity of individual surface hydroxyls, Margaretha Wagner, Bernd Meyer, Martin Setvin, Michael Schmid, Ulrike Diebold, Nature 592, 722 (2021).
    https://www.nature.com/articles/s41586-021-03432-3
  2. Measuring spin coherence times
    Single-molecule electron spin resonance by means of atomic force microscopy, Lisanne Sellies, Raffael Spachtholz, Sonja Bleher, Jakob Eckrich, Philipp Scheuerer, Jascha Repp. Nature 624, 64 (2023).
    https://www.nature.com/articles/s41586-023-06754-6
  3. Imaging molecular states far from the Fermi level
    Mapping orbital changes upon electron transfer with tunnelling microscopy on insulators, Laerte L. Patera, Fabian Queck, Philipp Scheuerer, Jascha Repp, Nature 566, 245 (2019).
    https://www.nature.com/articles/s41586-019-0910-3
  4. Measuring the force to move an atom
    The Force Needed to Move an Atom on a Surface, Markus Ternes , Christopher P. Lutz, Cyrus F. Hirjibehedin, Franz J. Giessibl, Andreas J. Heinrich, Science 319, 1066 (2008).
    https://www.science.org/doi/full/10.1126/science.1150288
  5. Resolving spin contrast
    Spin Resolution and Evidence for Superexchange on NiO(001) Observed by Force Microscopy, Florian Pielmeier, Franz J. Giessibl, Phys. Rev. Lett. 110, 266101 (2013).
    https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.110.266101
  6. Combining inelastic tunneling spectroscopy with force microscopy
    Vibrations of a molecule in an external force field, Norio Okabayashi, Angelo Peroni, Magnus Paulsson, Franz J. Giessibl, Proc. Natl. Acad. Sci. U.S.A. 115, 4571 (2018).
    https://www.pnas.org/doi/abs/10.1073/pnas.1721498115
  7. Lateral force microscopy
    Friction traced to the single atom, Franz J. Giessibl, Markus Herz, Jochen Mannhart, Proc. Natl. Acad. Sci. U.S.A. 99, 12006 (2002).
    https://www.pnas.org/doi/full/10.1073/pnas.182160599
    Quantifying molecular stiffness and interaction with lateral force microscopy, Alfred John Weymouth, Thomas Hofmann, Franz J Giessibl, Science 343, 1120 (2014).
    https://www.science.org/doi/full/10.1126/science.1249502
  8. Chemical synthesis and analysis
    Direct Imaging of Covalent Bond Structure in Single-Molecule Chemical Reactions, Dimas G. de Oteyza, Patrick Gorman, Yen-Chia Chen, Sebastian Wickenburg, Alexander Riss, Duncan J. Mowbray, Grisha Etkin, Zahra Pedramrazi, Hsin-Zon Tsai, Angel Rubio, Michael F. Crommie, Felix R. Fischer, Science 340, 1434 (2013).
    https://www.science.org/doi/10.1126/science.1238187
    An sp-hybridized molecular carbon allotrope, cyclo[18]carbon, Katharina Kaiser, Lorel M. Scriven, Fabian Schulz, Przemyslaw Gawel , Leo Gross, Harry L. Anderson, Science 365, 1299 (2019).
    https://www.science.org/doi/10.1126/science.aay1914
    On-surface synthesis of aromatic cyclo[10]carbon and cyclo[14]carbon, Luye Sun, Wei Zheng, Wenze Gao, Faming Kang, Mali Zhao, Wei Xu, Nature 623, 972 (2023).
    https://www.nature.com/articles/s41586-023-06741-x
  9. Molecular emitters
    A standing molecule as a single-electron field emitter, Taner Esat, Niklas Friedrich, F. Stefan Tautz, Ruslan Temirov, Nature 558, 573 (2018).
    https://www.nature.com/articles/s41586-018-0223-y
  10. Atomic force microscopy with a superconducting tip
    Attempts to test an alternative electrodynamic theory of superconductors by low-temperature scanning tunneling and atomic force microscopy, Angelo Peronio and Franz J. Giessibl, Phys. Rev. B 94, 094503 (2016)
    https://journals.aps.org/prb/abstract/10.1103/PhysRevB.94.094503
  11. Friction
    Atomic Structure Affects the Directional Dependence of Friction, A. J. Weymouth, D. Meuer, P. Mutombo, T. Wutscher, M. Ondracek, P. Jelinek, F. J. Giessibl, Phys. Rev. Lett. 111, 126103 (2013).
    https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.111.126103
    Superlubricity of graphene nanoribbons on gold surfaces, Shigeki Kawai, Andrea Benassi, Enrico Gnecco, Hajo Söde, Rémy Pawlak, Xinliang Feng, Klaus Müllen, Daniele Passerone, Carlo A. Pignedoli, Pascal Ruffieux, Roman Fasel, Ernst Meyer, Science 351, 957 (2016).
    https://www.science.org/doi/10.1126/science.aad3569
    Dynamic Friction Unraveled by Observing an Unexpected Intermediate State in Controlled Molecular Manipulation, Norio Okabayashi, Thomas Frederiksen, Alexander Liebig, Franz J. Giessibl, Phys. Rev. Lett. 131, 148001 (2023).
    https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.131.148001
  12. Probing bonds to artificial atoms
    Very weak bonds to artificial atoms formed by quantum corrals, Fabian Stilp, Andreas Bereczuk, Julian Berwanger, Nadine Mundigl, Klaus Richter, Franz J. Giessibl, Science 372, 1196 (2021).
    https://www.science.org/doi/full/10.1126/science.abe2600
  13. Visualizing edge states in a quantum Hall device
    Edge channels of broken-symmetry quantum Hall states in graphene visualized by atomic force microscopy, Sungmin Kim, Johannes Schwenk, Daniel Walkup, Yihang Zeng, Fereshte Ghahari, Son T. Le, Marlou R. Slot, Julian Berwanger, Steven R. Blankenship, Kenji Watanabe, Takashi Taniguchi, Franz J. Giessibl, Nikolai B. Zhitenev, Cory R. Dean, Joseph A. Stroscio, Nature Communications 12, 2852 (2021).
    https://www.nature.com/articles/s41467-021-22886-7

C) Operation in challenging environments

  1. Ambient AFM with atomic resolution
    Optimizing atomic resolution of force microscopy in ambient conditions, Daniel S. Wastl, Alfred J. Weymouth, Franz J. Giessibl, Phys. Rev. B 87, 245415 (2013).
    https://journals.aps.org/prb/abstract/10.1103/PhysRevB.87.245415
  2. AFM at ultralow temperatures in high magnetic fields
    Achieving μeV tunneling resolution in an in-operando scanning tunneling microscopy, atomic force microscopy, and magnetotransport system for quantum materials research, Johannes Schwenk, Sungmin Kim, Julian Berwanger, Fereshte Ghahari, Daniel Walkup, Marlou R Slot, Son T Le, William G Cullen, Steven R Blankenship, Sasa Vranjkovic, Hans J Hug, Young Kuk, Franz J Giessibl, Joseph A Stroscio, Rev. Sci. Instrum. 91, 071101 (2020).
    https://pubs.aip.org/aip/rsi/article/91/7/071101/840126
  3. Combined STM and AFM in electrochemistry
    Electrochemical AFM/STM with a qPlus sensor: A versatile tool to study solid-liquid interfaces,
    Andrea Auer, Bernhard Eder, Franz J. Giessibl, J. Chem. Phys. 159, 174201 (2023).
    https://pubs.aip.org/aip/jcp/article-abstract/159/17/174201/2919182
  4. Quantum sensing with NV centers
    Nanoscale electric-field imaging based on a quantum sensor and its charge-state control under ambient condition, Ke Bian, Wentian Zheng, Xianzhe Zeng, Xiakun Chen, Rainer Stöhr, Andrej Denisenko, Sen Yang, Jörg Wrachtrup, Ying Jiang, Nature Communications 12, 2457 (2021).
    https://www.nature.com/articles/s41467-021-22709-9
  5. AFM in biological environments
    Imaging in Biologically-Relevant Environments with AFM Using Stiff qPlus Sensors, Korbinian Pürckhauer, Alfred J. Weymouth, Katharina Pfeffer, Lars Kullmann, Estefania Mulvihill, Michael P. Krahn, Daniel J. Müller, Franz J. Giessibl, Scientific Reports 8, 9330 (2018).
    https://www.nature.com/articles/s41598-018-27608-6
    A Next-Generation qPlus-Sensor-Based AFM Setup: Resolving Archaeal S-Layer Protein Structures in Air and Liquid, Theresa Seeholzer, Daniela Tarau, Lea Hollendonner, Andrea Auer, Reinhard Rachel, Dina Grohmann, Franz J. Giessibl, Alfred J. Weymouth, J. Phys. Chem. B 127, 6949 (2023).
    https://pubs.acs.org/doi/abs/10.1021/acs.jpcb.3c02875
The qPlus® Sensor is commercially available by several fine manufacturers of atomic force microscopes:
The qPlus® poem

Long ago in a late night session,
Goethe’s Faust has raised the question:

Could we ever find out whether,
or what holds our world together.

Binnig, Quate, Gerber in nineteen eighty six,
created an instrument that did the tricks.

They called it atomic force microscope,
scientists worldwide were full of hope.

Could it really see, feel, push the atom,
elusive, far out, could we ever fathom?

If true the atomic force microscope we adore,
with its silicon cantilever at its core,

could see the atom in all its beauty,
calling scientists globally to the duty.

But must the core be a silicon cantilever,
or is there something slightly more clever?

Could one borrow from the makers of clocks?
A new approach that really rocks.

Yes there is a sensor named qPlus,
I tell you it is highly worthy to discuss.

Angstroms measure atomic dimensions,
but if you have somewhat higher intentions,

qPlus makes it much more sweeter,
its measure for distance is the picometer.

People thought all atoms here,
more or less look like a sphere.

However quite early qPlus revealed,
atoms have dents once well concealed.

This fascinated a titan in the domain of visual art,
in atomic studies Gerhard Richter took part.

Seeing structure within an atom out of the blue,
Richter just named his piece First View.

Followed by Graphite, Strontium and Silicate,
those were the first atoms in art up to this date.

How much force for an atom to push,
you don’t need to beat around the bush!

The pushing force, at least in a few lines,
was even reported by the New York Times.

qPlus tells you the precise force,
for the chemical bond’s divorce.

What is nickel oxide’s spin orientation?
qPlus provides its antiferromagnetic relation.

This beautiful world is full of wonder,
qPlus helps to reveal what is all under.

Scientists imaging molecules at IBM,
notice what brought success for them.

When attaching to the tip a CO molecule,
atoms appear very sharp with Paulis rule.

A young Humboldt fellow fairly recently,
introduced the qPlus to electrochemistry.

The Viennese queen of insulators,
no longer just relies on calculators.

Directly sees the oxygen’s location,
no need to compute the wave equation.

Molecular scientists were ramping,
voltage and found out that the damping,

revealed the molecular states on thick salty layers,
and thus became major chemical players.

A twisted sensor measures lateral forces,
offering brand new discovery sources.

It seems to the qPlus applications is no real limit,
the next breakthrough might come any minute.

© Franz J. Giessibl 2024

© Franz J. Giessibl 2025